Inclusion Criteria

Inclusion criteria:

1. Patients with confirmed histological or cytological diagnosis of advanced solid
tumours and for whom no proven therapy exists or who are not amenable to established
treatments.

2. Age 18 years or older.

3. Life expectancy of at least three months.

4. Eastern Cooperative Oncology Group (ECOG) performance score 0 or 1.

5. Patients previously treated and with asymptomatic brain metastases are eligible

6. Patients must have recovered from recent surgery.

Exclusion criteria:

1. Active infectious disease

2. Recent surgery within the last 4 weeks prior visit 1.

3. Chronic diarrhoea or gastrointestinal tract disease resulting in an inability to take
oral medication

4. History of haemorrhagic or thrombotic events

5. Significant cardiovascular diseases within

6. Current peripheral neuropathy > Common Terminology Criteria for Adverse Events
(CTCAE) grade 1 except due to trauma

7. Untreated or symptomatic brain metastases or leptomeningeal disease.

8. Treatment with an Epidermal growth Factor-receptor (EGFR)- or Heregulin Receptor 2
(HER2) inhibiting drug or antiangiogenic drug.

9. Therapeutic anticoagulation.

10. Female patients of childbearing potential.

11. Known pre-existing interstitial lung disease