Changes in Adrenal Hormones During Adrenal Radiofrequency Ablation
20 Years
N/A
Both
Adrenal Gland Neoplasms
Trial Information
Changes in Adrenal Hormones During Adrenal Radiofrequency Ablation
Adrenal radiofrequency (RF) ablation has been increasingly used for the treatment of
unresectable adrenal tumors. But one of the major complication is a increase in blood
pressure. Hormonal release during RF ablation is considered the cause of hypertension. But
there has been no evidence that adrenal hormones affects changes in blood pressure. In this
prospective study, we evaluate the changes in adrenal hormones during RF ablation and
clarify the cause of hypertensive crisis.
Inclusion Criteria:
- Unresectable adrenal tumor which will be treated by radiofrequency (RF)ablation
- Blood pressure is 140mmHg or less before RF ablation
- Age of 20-years or more
- Performance status of 0 or 1
- Agreement from the patient
Exclusion Criteria:
- Platelet count of 50,000/mm^3 or International normalized ratio (INR)>1.5
Type of Study:
Interventional
Study Design:
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
Increase in Catecholamine
Outcome Time Frame:
One day
Safety Issue:
No
Principal Investigator
Koichiro Yamakado, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Mie University School of Medicine
Authority:
Japan: Ministry of Health, Labor and Welfare
Study ID:
274
NCT ID:
NCT00997594
Start Date:
October 2009
Completion Date:
Related Keywords:
- Adrenal Gland Neoplasms
- adrenal gland
- Adrenal Gland Neoplasms
- Neoplasms
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