An Exploration of Factors Affecting Interest and Uptake of Genetic Testing for Prostate Cancer Susceptibility: The Clinical Application of Genetic Testing for Lower Risk Cancer Predisposition Genes
40 Years
69 Years
Male
Prostate Cancer
Trial Information
An Exploration of Factors Affecting Interest and Uptake of Genetic Testing for Prostate Cancer Susceptibility: The Clinical Application of Genetic Testing for Lower Risk Cancer Predisposition Genes
This study will use a mixed methods approach to follow men as they move through the genetic
testing process, from initial contact through to receiving their genetic testing results. A
questionnaire will be used to measure variables at both baseline and after proceeding
through the testing process. A small cohort of men will be invited to be interviewed to
gather some in depth qualitative data about the issues that have arisen during the study
process.
Inclusion Criteria:
- Men with a positive family history of prostate cancer. The definition of a positive
family history will be: Men with a first degree relative with prostate cancer
diagnosed at <70 years; Men with two relatives with prostate cancer where at least on
is diagnosed at <70 years; Men with three relatives with prostate cancer diagnosed at
any age
- Age 40-69 years
- No previous biopsy for raised PSA
- Absence of any psychological, familial, sociological or geographic situation
potentially hampering compliance with the study protocol and follow-up schedule.
Exclusion Criteria:
- Previous prostate cancer
- Men from families where there is known to be a mutation in a high-risk prostate
cancer gene
- Men who have had a prostate biopsy within the last 12 months.
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Prospective
Outcome Measure:
Whether cancer worry changes between the two time-points (measured using the Impact of Event Scale)
Safety Issue:
No
Principal Investigator
Dr Rosalind Eeles
Investigator Role:
Principal Investigator
Investigator Affiliation:
Institute of Cancer Research, United Kingdom
Authority:
United Kingdom: Research Ethics Committee
Study ID:
CCR3200
NCT ID:
NCT00997464
Start Date:
August 2009
Completion Date:
February 2011
Related Keywords:
- Prostate Cancer
- Disease Susceptibility
- Prostatic Neoplasms
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