Inclusion Criteria:

- Proband with one of the following (both incident and prevalent cases will be
collected):

- Colorectal cancer diagnosed at or under the age of 50.

- Breast cancer diagnosed at or under the age of 45.

- Germ cell tumor diagnosed at or under the age of 40.

- Pediatric neuroblastoma or primary bone sarcoma diagnosed at or under the age of
21.

- Cancer of any type diagnosed at or under the age of 40

- Proband must have living unaffected biologic mother and father available and
eligible for participation in the study.

- Unaffected parents:

- Must be the biologic mother and biologic father of affected proband.

- Must have (by self-report) no history of cancer other than non-melanomatous skin
cancer or cervical cancer in situ.

- Unaffected sibling(s):

- Must be age 18 or older and have same biologic parents as proband.

Exclusion Criteria:

- Known genetic mutation in proband or a family history that is indicative of
hereditary cancer susceptibility.