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Genomic Structural Variation in Cancer Susceptibility


N/A
N/A
N/A
Open (Enrolling by invite only)
Both
Breast Cancer, Colon Cancer, Germ Cell Cancer, Neuroblastoma, Rectal Cancer, Sarcoma

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Trial Information

Genomic Structural Variation in Cancer Susceptibility


Inclusion Criteria:



- Proband with one of the following (both incident and prevalent cases will be
collected):

- Colorectal cancer diagnosed at or under the age of 50.

- Breast cancer diagnosed at or under the age of 45.

- Germ cell tumor diagnosed at or under the age of 40.

- Pediatric neuroblastoma or primary bone sarcoma diagnosed at or under the age of
21.

- Cancer of any type diagnosed at or under the age of 40

- Proband must have living unaffected biologic mother and father available and
eligible for participation in the study.

- Unaffected parents:

- Must be the biologic mother and biologic father of affected proband.

- Must have (by self-report) no history of cancer other than non-melanomatous skin
cancer or cervical cancer in situ.

- Unaffected sibling(s):

- Must be age 18 or older and have same biologic parents as proband.

Exclusion Criteria:

- Known genetic mutation in proband or a family history that is indicative of
hereditary cancer susceptibility.

Type of Study:

Observational

Study Design:

Observational Model: Family-Based

Outcome Measure:

To determine the frequency of de novo germline copy number variants (CNVs) in cancer affected probands using an ascertainment of "trios" consisting of cancer patients and their unaffected biologic parents

Outcome Time Frame:

2 years

Safety Issue:

No

Principal Investigator

Zsofia Stadler, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

09-068

NCT ID:

NCT00996710

Start Date:

October 2009

Completion Date:

October 2013

Related Keywords:

  • Breast Cancer
  • Colon Cancer
  • Germ Cell Cancer
  • Neuroblastoma
  • Rectal Cancer
  • Sarcoma
  • Genome-wide
  • 09-068
  • Breast Neoplasms
  • Colonic Neoplasms
  • Rectal Neoplasms
  • Disease Susceptibility
  • Neuroblastoma
  • Neoplasms, Germ Cell and Embryonal
  • Sarcoma

Name

Location

Memorial Sloan Kettering Cancer CenterNew York, New York  10021