Inclusion Criteria:

- Age: less than or equal to 18 years of age. May be greater than 18 years of age if
currently a St. Jude patient.

- Patients with relapsed or refractory B-lineage ALL who are not eligible for
hematopoietic stem cell transplantation (HSCT) because their leukemia is not in
remission (>5% blasts in bone marrow as evidenced either by morphology or by flow
cytometry).

- Shortening fraction greater than or equal to 25%.

- Glomerular filtration rate greater than or equal to 50 cc/min/1.73 m2.

- Pulse oximetry greater than or equal to 92% on room air.

- Direct bilirubin less than or equal to 3.0 mg/dL.

- Alanine aminotransferase (ALT) is no more than 2 times the upper limit of normal.

- Aspartate transaminases (AST) is no more than 2 times the upper limit of normal.

- Karnofsky or Lansky performance score of greater than or equal to 50.

- No known allergy to murine products or HAMA testing results within normal limits.

- No prior receipt of a gene-transfer agent (e.g. retroviral, adenoviral, lentiviral
vector).

- Does not have a current pleural or pericardial effusion.

- Has a suitable adult family member donor available for NK cell donation.

- Has recovered from all acute NCI Common Toxicity Criteria grade II-IV non-hematologic
acute toxicities resulting from previous therapy as per the judgment of the principal
investigator.

- At least two weeks since receipt of any biological therapy, systemic chemotherapy,
and/or radiation therapy.

- Is not receiving more than the equivalent of prednisone 10 mg daily.

Exclusion Criteria:

- Pregnant (negative serum or urine pregnancy test to be conducted within 7 days prior
to enrollment)

- Breastfeeding