Inclusion Criteria:

DISEASE CHARACTERISTICS

- Histologically confirmed primary adenocarcinoma of the stomach

- 3-4weeks after radical operation for gastric cancer

- Stage of the gastric cancer was T3-4NxM0

PATIENT CHARACTERISTICS:

- Age: 18 - 70years old

Life expectancy:

- Longer than 3 months

Hematopoietic:

- Granulocyte count at least 1,500/mm3

- Platelet count at least 100,000/mm3

- Hemoglobin at least 80*10^12/mm3

Hepatic:

- AST no greater than 2.5 times ULN

Renal:

- Creatinine no greater than 1.5 times ULN

Other:

- Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- Not specified

Chemotherapy:

- Prior chemotherapy and radiotherapy were not allowed

- No other concurrent chemotherapy

Radiotherapy:

- Locally radiotherapy for local disease of advanced gastric cancer during adjuvant
treatment was allowed

Surgery:

- See Disease Characteristics

- Prior surgery for gastric cancer was necessary

Exclusion Criteria:

- Haven't recovery from operation or complication of operation

- With the following risk factors: Uncontrolled or severe cardiovascular disease (e.g.,
myocardial infarction within the past 6 months, congestive heart failure treated with
medications, or uncontrolled hypertension)

- Pregnant or nursing

- Other currently active malignancy except nonmelanoma skin cancer

- Uncontrolled or severe bleeding,diarrhea,intestinal obstruction,adhesion of intestine

- metastasis before enrollment

- Received other chemotherapy or radiotherapy after operation