Inclusion Criteria:

- Known BRCA1 or BRCA2 carrier (regardless of age)

- Any mutation carrier in hereditary breast cancer susceptibility genes that is known
to increase the risk for breast cancer (regardless of age). Some examples of these
would include TP53, PTEN, BRCA1 and BRCA2, CHEK2, ATM, and CDH1.

- For women who chose not to have genetic testing or test negative, probability of
being a BRCA1 or BRCA2 carrier of 20% or greater based on BRCAPRO analysis or ≥ 25%
risk of being a mutation carrier by Couch model in addition to a lifetime breast
cancer risk >=20% by Gail, CARE, or Claus model

- Personal history of breast cancer before age 35 years

- Any woman of African ancestry whose 1st degree relative (mother or sister) or 2nd
degree relative (aunt, grandmother) if paternal lineage suspected diagnosed with
breast cancer under age 40, regardless of risk calculation

- Have a personal history of ductal carcinoma in situ (DCIS) diagnosed at or before age
35 AND a first degree relative who had been diagnosed with breast cancer before age
50 OR has a first degree relative diagnosed with ovarian cancer at any age

- Any female cancer survivor who received chest irradiation before age 30 for any
disease including Hodgkin's, a sarcoma, neuroblastoma, or other medical condition.

Exclusion Criteria:

Women will be excluded if they meet one of the following:

- active cancer at the time of enrollment. A prior history of breast cancer is
permitted if the subject has completed chemotherapy and is considered disease-free at
the time of enrollment.

- current pregnancy

- presence of a pacemaker or any other metallic foreign objects in their body that
interferes with an MRI

- breast surgery within two weeks of study entry

- previous bilateral mastectomy (prophylactic or therapeutic)

- history of kidney disease or abnormal kidney tests

- Women who test negative in a family with identifiable BRCA mutations are ineligible
regardless of risk calculation