Inclusion Criteria:

- Subjects with pathologically or cytologically documented stage IIIB or IV NSCLC.
Disease must be newly diagnosed .

- Presence of at least 1 uni-dimensionally measurable index lesion,with the longest
diameter ≥ 20 mm using conventional computer tomography(CT)/magnetic resonance
imaging(MRI)scan or ≥ 10 mm using spiral computed tomography scan.

- Age > 18 and < 65, with ECOG performance status 0-1,and Life expectancy of more than
3 months.

- functions of major organs (haemogram, heart, liver, kidney) are basically normal,
White blood count ≥3.5 x 109/L with neutrophils ≥1.5 x 109/L, platelet count≥100 x
109/L, and hemoglobin ≥100g/L. Total bilirubin ≤1.5 times upper limit of normal (ULN)
range; alkaline phosphatase(ALP)≤ 2.5 times ULN or ≤5 times ULN (liver metastasis);
Transaminases AST (SGOT) and ALT (SGPT) ≤ 2.5 times ULN or ≤ 5 times ULN (liver
metastasis). serum creatinine ≤ 1.2 times ULN, blood urea nitrogen≤ 1.2 times ULN.

- both female and male patients must use adequate methods of contraception.

- without other malignancy history, except curative carcinoma in situ of cervix and
skin basal cell carcinoma.

- willing and able to comply with scheduled visits, treatment plan, laboratory tests,
and other study procedures.

Exclusion Criteria:

- Previous radiotherapy（except the radiotherapy of brain metastasis）, Previous
chemotherapy or anticancer biotherapy , Participation other clinical trials within 1
month prior to inclusion in the trial.

- With only unmeasureable lesion, ie, hydrothorax, ascites, lymphangitis carcinomatous,
diffuse liver metastasis, bony metastasis; no measureable lesion or the lesion could
not be determined.

- Pregnant or breast-feeding women or using a prohibited contraceptive method.

- With Symptomatic brain metastasis not controlled.

- with an uncontrolled seizure disorder, or active centre neurological disease, or
Psychiatric disease affected cognitive ability; physiogenic or pathological
dystrophinopathies, chronic diarrhea, cachexia.

- with significant history of cardiac disease, i.e., congestive heart failure, angina
requiring medication, uncontrolled cardiac ventricular arrythmias, heart valve
disease, serious myocardial infarction, uncontrolled hypertension.

- With other serious internal diseases or uncontrolled infection.

- With drug addition,ie,drug-taking,drug-taking for long time;with AIDS.

- With organ transplantation,or using adrenocortical hormone or immunosuppressive
agents for long time.

- With history of serious allergic or allergy.

- Not fit for the clinical trial judged by the investigator.