Phase II Study of Combined Modality Treatment for Resectable Non-Small Cell Superior Sulcus Tumors
Eligible (surgically resectable and medically operable) patients will have surgery followed
by radiation therapy, given twice daily, for 5 weeks if margins are negative and for 5-1/2
weeks for positive margins. Grossly positive margins can be treated by brachytherapy
followed by external radiotherapy.
Concomitant chemotherapy consisting of cisplatin given intravenously on days 1 and 8, and
etoposide taken by mouth 30-60 minutes prior to each radiotherapy treatment x the first 10
days. The cycle will be repeated start day 29.
If the patients are considered to have no evidence of disease in one month after completion
of chemotherapy, optional prophylactic radiotherapy to the brain will be give in 10
fractions once daily for 2 weeks.
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Patient Outcomes Following Surgery and Accelerated Radiation Therapy/Chemotherapy
One month after completion of chemotherapy
Ritsuko Komaki, MD
M.D. Anderson Cancer Center
United States: Institutional Review Board
|U.T. M.D. Anderson Cancer Center||Houston, Texas 77030|