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Prospective Study of the Effects of Helicobacter Pylori Eradication on Renal Functions and Proteinuria in Patients With Membranous Nephropathy


N/A
18 Years
70 Years
Not Enrolling
Both
Nephrotic Syndrome, Glomerulonephritis, Membranous Nephropathy

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Trial Information

Prospective Study of the Effects of Helicobacter Pylori Eradication on Renal Functions and Proteinuria in Patients With Membranous Nephropathy


Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. It is thought
to be mainly a primary or idiopathic form; however, it may also be secondary to many other
diseases (e.g., infections, drugs, neoplasms and autoimmune diseases). In this study, the
presence of Helicobacter Pylori antigen was investigated in renal tissue from needle biopsy
samples, and the prevalence of H. pylori infection and the effects of H. pylori eradication
on proteinuria level in patients with MN will be investigated.


Inclusion Criteria:



- Age between 18-70 years

- Nondiabetic patients

- Patients with primary glomerulonephritis

- Clinical diagnosis of membranous nephropathy, IgA nephropathy or focal segmental
glomerulosclerosis confirmed by biopsy

- Glomerular filtration rate > 30 mL/min

- Patients who did not receive Helicobacter pylori eradication therapy within the last
three months before enrollment in study

Exclusion Criteria:

- Patients with secondary glomerulonephritis

- Glomerular filtration rate < 30 mL/min

- Patients who received Helicobacter pylori eradication therapy within the last three
months before enrollment in study

- Patients with a history of gastric surgery

- Patients without an informed consent

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Outcome Measure:

Daily proteinuria levels after Helicobacter Pylori eradication treatment

Outcome Time Frame:

6 months

Safety Issue:

Yes

Principal Investigator

Yasar Caliskan, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University

Authority:

Turkey: Ethics Committee

Study ID:

20061976

NCT ID:

NCT00983034

Start Date:

March 2006

Completion Date:

July 2009

Related Keywords:

  • Nephrotic Syndrome
  • Glomerulonephritis
  • Membranous Nephropathy
  • nephrotic syndrome
  • Helicobacter pylori infection
  • proteinuria
  • membranous nephropathy
  • Glomerulonephritis
  • Glomerulonephritis, Membranous
  • Kidney Diseases
  • Nephrotic Syndrome
  • Proteinuria

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