Study of Imaging of Viral Thymidine Kinase Activity in EBV-Associated and KSHV-Associated Malignancies
EBV and KSHV are associated with a variety of malignancies including some lymphomas,
carcinomas and other malignancies. We anticipate that viral TK expression will differ among
tumor types and will be adjusted with standard chemotherapies and some investigational
agents. This exploratory study is aimed in part at evaluating whether standard regimens or
investigational regimens might bring about sufficient activation of the EBV-TK or KSHV-TK in
tumors to be therapeutically useful if used in conjunction with FIAU as a
Allocation: Non-Randomized, Endpoint Classification: Bio-equivalence Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
To evaluate the potential for enzymatic targeting as evidenced by the ability to image 124I-FIAU tracer uptake in tumor at baseline and following chemotherapy or biologic therapy with agents that may induce viral TK activation.
Baseline, Days 1-3 post chemo
Yvette Kasamon, M.D.
Johns Hopkins University
United States: Institutional Review Board
|Sidney Kimmel Comprehensive Cancer Center||Lutherville, Maryland|