Evaluation of Serum Free Light Chains and Clonal Ig DNA in Plasma From Patients With Aggressive B-Cell Lymphomas
- To estimate the proportion of patients with diffuse large B-cell/immunoblastic and
Burkitt histologies with elevated serum free light chains (FLC).
- To estimate the proportion of patients with Hodgkin lymphoma with clonal immunoglobulin
(Ig) DNA detection in the plasma.
- To estimate the agreement between the detection of a monoclonal Ig DNA spike in plasma
and the detection of a monoclonal DNA spike in tumor tissue.
- To estimate the agreement between the fragment length of a spike in tumor tissue and
the fragment length of the spike in plasma.
- To estimate the detection rate of elevated FLC in each histology, including diffuse
large B-cell/immunoblastic and Burkitt lymphoma.
- To estimate the detection rate of clonal Ig DNA in each histology, including diffuse
large B-cell/immunoblastic, Burkitt lymphoma, and Hodgkin lymphoma.
- To analyze clinical and pathologic correlates of detection by the serum/plasma tests:
disease subtype, stage of disease, disease bulk, lactate dehydrogenase, and Ki-67
- To estimate the detection rate of clonotypic B-cells in peripheral blood mononuclear
cells from patients with Hodgkin lymphoma.
OUTLINE: This is a multicenter study.
Blood and tissue samples collected at the time of diagnosis are analyzed for serum free
light chain and clonal immunoglobulin (Ig) DNA rearrangements and circulating clonotypic
B-cells via PCR.
PROJECTED ACCRUAL: A total of 50 patients (25 with diffuse large B-cell/immunoblastic
histologies, 15 with Burkitt lymphoma, and 10 with Hodgkin lymphoma) will be accrued for
Observational Model: Cohort, Time Perspective: Prospective
Proportion of patients with diffuse large B-cell/immunoblastic and Burkitt histologies with elevated serum free light chains (FLC)
Nina Wagner-Johnston, MD
Mallinckrodt Institute of Radiology at Washington University Medical Center
United States: Federal Government
|Memorial Sloan-Kettering Cancer Center||New York, New York 10021|
|Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins||Baltimore, Maryland 21231-2410|
|Rebecca and John Moores UCSD Cancer Center||La Jolla, California 92093-0658|
|Baylor University Medical Center - Houston||Houston, Texas 77030-2399|
|Montefiore Medical Center||Bronx, New York 10467-2490|
|UCSF Helen Diller Family Comprehensive Cancer Center||San Francisco, California 94115|
|Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis||St. Louis, Missouri 63110|
|UCLA Clinical AIDS Research and Education (CARE) Center||Los Angeles, California 90024|
|Boston University Cancer Research Center||Boston, Massachusetts 02118|
|Mallinckrodt Institute of Radiology at Washington University Medical Center||St. Louis, Missouri 63110|
|University of Miami||Miami, Florida 33136|
|Pennsylvania Oncology Hematology Associates, Incorporated - Philadelphia||Philadelphia, Pennsylvania 19106|
|Benaroya Research Institute at Virginia Mason Medical Center||Seattle, Washington 98101|
|University of California at Davis Center for Aids Research and Education Services||Sacramento, California 95814|
|Thomas Street Health Center||Houston, Texas 77009|
|UNC Hospitals, The University of North Carolina at Chapel Hill||Chapel Hill, North Carolina 27599|