Investigation of Thioredoxin-1 Family Protein Expression in Rectal Cancer
18 Years
N/A
Both
Colorectal Cancer
Trial Information
Investigation of Thioredoxin-1 Family Protein Expression in Rectal Cancer
OBJECTIVES:
- Determine expression levels of thioredoxin-1 (Trx-1), thioredoxin-interacting protein
(TXNIP), and hypoxia inducible factor-1 alpha (HIF-1α) in paraffin-embedded resected
tumor tissue samples from patients with stage II or III rectal cancer enrolled in
clinical trial SWOG-9304.
- Determine if there is a correlation between Trx-1 and TXNIP expression and HIF-1α
expression.
- Correlate expression of these proteins with tumor stage, disease-free survival, overall
survival, and risk of recurrence.
- Determine interactions for patient age, performance status, and type of therapy
received on clinical trial SWOG-9304.
OUTLINE: This is a multicenter study.
Paraffin-embedded resected tumor tissue samples are analyzed for protein expression levels
(thioredoxin-1, thioredoxin-interacting protein, and hypoxia inducible factor-1 alpha) by
tissue microarray and immunostaining.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Histologically confirmed adenocarcinoma of the rectum
- Stage II or III disease
- No metastases
- Enrolled on clinical trial SWOG-9304
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Retrospective
Outcome Measure:
Expression of thioredoxin-1, thioredoxin-interacting protein, and hypoxia inducible factor-1 alpha
Outcome Time Frame:
upon testing of specimens
Safety Issue:
No
Principal Investigator
Tomislav Dragovich, MD, PhD
Investigator Role:
Study Chair
Investigator Affiliation:
University of Arizona
Authority:
United States: Federal Government
Study ID:
CDR0000601255
NCT ID:
NCT00972751
Start Date:
February 2009
Completion Date:
September 2010
Related Keywords:
- Colorectal Cancer
- stage II rectal cancer
- stage III rectal cancer
- adenocarcinoma of the rectum
- Rectal Neoplasms
- Colorectal Neoplasms
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