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The Relationship Between the Growth Hormone (GH)- Insulin Like Growth Factor I (IGF-I) System and the Inflammatory System in Healthy Normal Persons


N/A
22 Years
65 Years
Open (Enrolling by invite only)
Both
Interaction Between the GH/IGF-I System and the Immune-system

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Trial Information

The Relationship Between the Growth Hormone (GH)- Insulin Like Growth Factor I (IGF-I) System and the Inflammatory System in Healthy Normal Persons


To investigate if administration of 3 weeks og GH (10-30 microgram/kg/day) and subsequent
Pegvisomant (10-15 mg/day) influence serum concentrations of the inflammatory variables
Tumor Necrosis Factor α (TNF-α), Interleukin-6 (IL-6), high sensitive CRP (hsCRP) and the
newly discovered acute phase protein YKL-40. The study involves 12 healthy volunteers age
from 22-65 years.


Inclusion Criteria:



- Healthy, normal blood tests

Exclusion Criteria:

- Previous cancer

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Outcome Measure:

The relationship between changes in serum levels of Tumor Necrosis Factor α (TNF-α), Interleukin-6 (IL-6), high sensitive CRP (hsCRP) and YKL-40 vs. changes in serum levels og IGF-I

Outcome Time Frame:

1/9 2009 - 1/3 2010

Safety Issue:

Yes

Authority:

Denmark: Ethics Committee

Study ID:

HC-2009-049

NCT ID:

NCT00969644

Start Date:

September 2009

Completion Date:

March 2010

Related Keywords:

  • Interaction Between the GH/IGF-I System and the Immune-system

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