The Relationship Between the Growth Hormone (GH)- Insulin Like Growth Factor I (IGF-I) System and the Inflammatory System in Healthy Normal Persons
To investigate if administration of 3 weeks og GH (10-30 microgram/kg/day) and subsequent
Pegvisomant (10-15 mg/day) influence serum concentrations of the inflammatory variables
Tumor Necrosis Factor α (TNF-α), Interleukin-6 (IL-6), high sensitive CRP (hsCRP) and the
newly discovered acute phase protein YKL-40. The study involves 12 healthy volunteers age
from 22-65 years.
Interventional
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
The relationship between changes in serum levels of Tumor Necrosis Factor α (TNF-α), Interleukin-6 (IL-6), high sensitive CRP (hsCRP) and YKL-40 vs. changes in serum levels og IGF-I
1/9 2009 - 1/3 2010
Yes
Denmark: Ethics Committee
HC-2009-049
NCT00969644
September 2009
March 2010
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