Inclusion Criteria:

- Histologically or cytologically confirmed ``extensive disease`` (Stage T0-4 N0-3 M1)
small cell lung cancer

- At least one measurable disease site, defined as lesion of ≥ 1 cm unidimensionally on
CT-scan.

- WHO performance status 0-2

- Absolute neutrophil count at least 1800/µl and platelets at least 100000/µl and
hemoglobin at least 6.2 mmol/l.

- Calculated creatinine clearance at least 60 ml/min

- Adequate hepatic function: Total bilirubin ≤ 1.5 x upper limit of normal (ULN) for
the institution; ALT, AST, and alkaline phosphatase ≤ 2.5 x ULN for the institution
(in case of liver metastases ≤ 5 x ULN for the institution)

- No previous platinum chemotherapy or topo-isomerase-inhibitors for SCLC.

- Life expectancy more than 6 months

- Willing and able to comply with the study prescriptions

- 18 years or older

- Not pregnant or breast feeding and willing to take adequate contraceptive measures
during the study

- Ability to give and having given written informed consent before patient registration

- No mixed pathology, e.g. non-small cell plus small cell cancer

- No recent (< 3 months) severe cardiac disease (NYHA class >1) (congestive heart
failure, infarction)

- No history of cardiac arrythmia (multifocal premature ventricular contractions,
uncontrolled atrial fibrillation, bigeminy, trigeminy, ventricular tachycardia) which
is symptomatic and requiring treatment (CTC AE 4.0), or asymptomatic sustained
ventricular tachycardia. Asymptomatic atrial fibrillation controlled on medication is
allowed.

- No cardiac conduction disturbances or medication potentially causing them:

- QTc interval prolongation with other medications that required discontinuation of the
treatment

- Congenital long QT-syndrome or unexplained sudden death of first degree relative
under 40 years of age

- QTc interval > 480 msec (note: when this is the case on screening ECG, the ECG may be
repeated twice. If the average QT-interval of these 3 measurements remains below 480
msec, patient is eligible)

- Patients on medication potentially prolongating the QT-interval are excluded if the
QT-interval is > 460 msec (Appendix, table 2).

- Medication that might cause QT-prolongation or Torsades de pointes tachycardia is not
allowed (Appendix, Table 1). Drugs with a risk of prolongating the QT-interval that
cannot be discontinued are allowed, however, under close monitoring by the treating
physician (Appendix, table 2).

- No uncontrolled infectious disease

- No other active malignancy

- No major surgery (excluding diagnostic procedures like e.g., mediastinoscopy) in
previous 4 weeks

- No treatment with investigational drugs in 4 weeks prior to or during this study

- No chronic systemic immune therapy

- No known G6PD deficiency

Exclusion Criteria:

- The opposite of the above