Selective Use of Postoperative Radiotherapy AftEr MastectOmy - SUPREMO
- Determine the overall survival of women at intermediate risk for locoregional
recurrence of breast cancer treated with ipsilateral chest wall adjuvant radiotherapy
OUTLINE: This is a multicenter study. Patients are randomized to 1 of 2 treatment arms.
- Arm I: Beginning 12 weeks after mastectomy or 6 weeks after adjuvant chemotherapy,
patients undergo radiotherapy 5 days a week for 3-5 weeks in the absence of disease
progression or unacceptable toxicity.
- Arm II: Patients receive standard of care and observation only. After completion of
study therapy, patients are followed up twice in the first year, and then annually for
up to 10 years.
Allocation: Randomized, Primary Purpose: Treatment
Ian H. Kunkler, MD
Edinburgh Cancer Centre at Western General Hospital