Inclusion Criteria:

1. Patients diagnosed with high risk recurrent or refractory solid tumors following
initial chemotherapy

2. Tumor must be sensitive to chemotherapy (maximum 8 cycles) and/or radiation defined
as a greater than 50% reduction in size of the primary and/or metastatic sites.

3. Patients who are under 35 years of age.

4. Patients with a life expectancy of at least 8 weeks and performance status (Karnofsky
or Lansky score) of at least 70%.

5. Patients who are acceptable candidates for peripheral blood stem cell transplantation
based on their pre-transplant evaluation.

Exclusion Criteria:

1. Patients will not be excluded based on sex, race.

2. Patients with central nervous system tumors are not eligible for this protocol.

3. Patients have significant functional deficits in major organs which would interfere
with successful outcome following PBSCT.

4. Patients who have been treated for infections must have appropriate responses as
documented by negative cultures and/or a normal radiographic examination.

5. Patients may not have active CNS disease or marrow involvement with the tumor at the
time of transplant.

6. Patients with disease progression after tandem PBSC #1 will not be eligible for
tandem PBSC #2.

7. Patients will be excluded if they are women of childbearing potential who are
currently pregnant (HCG+) or who are not practicing adequate contraception.

8. Patients who have had a previous stem cell transplant.