Inclusion Criteria:

1. Subject who signed the written consent form by themselves, protectors or legal
representatives prior to the clinical trial after the person in charge explained
fully about objectives, procedure and the characteristics of the study drug.

2. Patient aged 18 to 75

3. Patient with pathologically-confirmed, advanced pancreatic cancer

4. ECOG scale (ECOG-PS) ≤2 (Appendix 4. Performance status scale/score)

5. Patient with anticipated survival period of more than 3 months

6. Patient with progressed disease after Gemcitabine-based primary anti-cancer
chemotherapy

7. Patient whose blood test, renal function test and liver function test results meet
the following conditions.

Exclusion Criteria:

1. Patient with the medical history of immunodeficiency or autoimmune disease that could
be aggravated by immunotherapy (examples: rheumatoid arthritis, systemic lupus
erythematosus, vasculitis, multiple sclerosis, adolescent Insulin-Dependent Diabetes
Mellitus, etc.)

2. Confirmed immunodeficient patient

3. Patient with the history of cancer other than skin cancer, local prostate cancer or
carcinoma in situ of cervix within the last 5 years of the start of study

4. Patient who has received systemic anti-angiogenic agent

5. Patient who has received a chemotherapy other than Gemcitabine based chemotherapy

6. Obvious myocardial failure or uncontrolled arterial hypertension

7. Patient who has experienced serious allergy (judged by the investigator)

8. Patient with serious psychological disease (judged by the investigator)

9. Pregnant woman, breast-feeding woman or woman who want to be pregnant during the
trial period

10. Patient who has participated in another clinical trial within the last 4 weeks of the
start of study