Study of Positron Emission Tomography With 18-fluorodeoxyglucose in Detecting Cancer in Patients With Idiopathic Venous Thromboembolism
18 Years
N/A
Both
Thromboembolism, Unspecified Adult Solid Tumor, Protocol Specific
Trial Information
Study of Positron Emission Tomography With 18-fluorodeoxyglucose in Detecting Cancer in Patients With Idiopathic Venous Thromboembolism
OBJECTIVES:
Primary
- Demonstrate the efficacy, in terms of increased numbers of cancer diagnoses, of PET-CT
with 18-FDG in patients with idiopathic venous thromboembolism.
Secondary
- Assess the risk of cancer detected at 1 year.
- Assess whether PET allows earlier detection of cancer.
- Evaluate survival.
OUTLINE: This is a multicenter study.
All patients undergo standard (clinical and biological) diagnostic tests for cancer.
Patients are randomized to 1 of 2 diagnostic arms.
- Arm I: Patients undergo diagnostic fludeoxyglucose F 18 PET in addition to standard
methods.
- Arm II: Patients only undergo standard diagnostic methods. Patients are followed up for
2 years.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of idiopathic venous thromboembolism (IVTE) meeting 1 of the following
criteria:
- Newly diagnosed
- Recurrent disease controlled by anticoagulant therapy
- No IVTE caused by a reversible major risk factor
- No IVTE caused by a major constitutional risk factor, including any of the following:
- Antiphospholipid antibody syndrome
- Antithrombin deficit
- Protein C
- Protein S
PATIENT CHARACTERISTICS:
- Not pregnant
- No other known active cancer at the onset of IVTE
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Primary Purpose: Diagnostic
Outcome Measure:
Number of cancers diagnosed
Safety Issue:
No
Principal Investigator
Pierre-Yves Salaun, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
CHU Brest - Hopital De La Cavale Blanche
Authority:
Unspecified
Study ID:
CDR0000639720
NCT ID:
NCT00964275
Start Date:
March 2009
Completion Date:
Related Keywords:
- Thromboembolism
- Unspecified Adult Solid Tumor, Protocol Specific
- unspecified adult solid tumor, protocol specific
- thromboembolism
- Thromboembolism
- Venous Thromboembolism
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