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Phase II Single-Arm Trial Comparing the Use of FLT PET to Standard Computed Tomography to Assess the Treatment Response of Neoadjuvant Docetaxel and Cisplatin in Stage IB-IIIA Resectable Non-Small Cell Lung Cancer


Phase 2
19 Years
N/A
Open (Enrolling)
Both
Recurrent Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer, Stage IIB Non-small Cell Lung Cancer, Stage IIIA Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer

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Trial Information

Phase II Single-Arm Trial Comparing the Use of FLT PET to Standard Computed Tomography to Assess the Treatment Response of Neoadjuvant Docetaxel and Cisplatin in Stage IB-IIIA Resectable Non-Small Cell Lung Cancer


PRIMARY OBJECTIVES:

I. To determine if the absolute decrease measured in primary tumor 18
F-F-3'-fluoro-3'-deoxy-L-thymidine (FLT) uptake (standard uptake value [SUV] and influx
constant [Ki]) between pre-treatment imaging and imaging after the first cycle of therapy
differs in patients categorized as responders or non-responders based on Response Evaluation
Criteria in Solid Tumors (RECIST) measured with computed tomography (CT) after the second
cycle of therapy.

SECONDARY OBJECTIVES:

I. To determine if the absolute decrease measured in primary tumor FDG uptake (SUV) between
pre-treatment imaging and imaging after the first cycle of therapy differs in patients
categorized as responders or non-responders based on RECIST measured with CT after the
second cycle of therapy.

II. To assess the effects of the combination of docetaxel and cisplatin on fractional tumor
viability and proliferative fraction pre and post treatment and to correlate these with the
PET SUV data for both tracers.

III. To assess the methylation status of the checkpoint with forkhead and ring finger
domains gene (CHFR) gene from pre-treatment tumor biopsies and correlate methylation status
post treatment with clinical and pathologic response.

OUTLINE:

Patients receive docetaxel intravenously (IV) and cisplatin IV on day 1 and dexamethasone
orally (PO) twice daily (BID). Treatment repeats every 3 weeks for 2 courses in the absence
of disease progression or unacceptable toxicity. Patients undergo FDG PET/CT, FLT PET/CT,
and thoracic CT at baseline and the end of courses 1 and 2 and then undergo surgery.

After completion of study treatment, patients are followed up for 4-6 weeks.


Inclusion Criteria:



- Patients must have histologically or cytologically confirmed clinical stage IB - IIIA
non-small cell lung cancer; stage IV patients with oligometastatic disease with
metastases that have been treated definitively with radiation or surgery are also
eligible (ie: solitary brain or adrenal metastasis); mixed tumors will be categorized
by the predominant cell type unless small cell elements are present in which case the
patient is ineligible; note: tissue samples from biopsy confirmation will be required

- Patients must be surgically resectable as determined by a thoracic surgeon

- Patients must have measurable disease per RECIST 1.1, defined as at least one lesion
that can be accurately measured in at least one dimension (longest diameter to be
recorded) as >= 10 mm with spiral CT scan

- Life expectancy of greater than 12 weeks

- ECOG performance status < 1

- Leukocytes >= 3,000/uL

- Absolute neutrophil count >= 1,500/uL

- Platelets >= 100,000/uL

- Total bilirubin =< 1.5 x institutional upper limit of normal

- AST (SGOT) =< 1.5 x institutional upper limit of normal

- Alkaline phosphatase =< 2.5 x institutional upper limit of normal

- Creatinine =< 1.5 x institutional upper limit of normal OR creatinine clearance >= 60
mL/1.73 m2 for patients with creatinine levels above institutional normal

- Fasting screening blood glucose =< 200 mg/dL

- Pregnant women are excluded from this study; breastfeeding should be discontinued if
the mother is treated with either agent

Exclusion Criteria:

- Women of child-bearing potential and men must agree to use adequate contraception
(hormonal or barrier method of birth control; abstinence) prior to study entry and
for the duration of study participation; should a woman become pregnant or suspect
she is pregnant while participating in this study, she should inform her treating
physician immediately

- Patients may not be receiving any other investigational agents

- Patients must not have received prior systemic chemotherapy or radiation therapy for
lung cancer; prior systemic chemotherapy or radiation for other malignancies over
three years prior to study enrollment may be allowed at the discretion of the
principal medical investigator

- Prior malignancy in the past 3 years, other than non-melanoma skin cancer and in situ
carcinoma of the cervix

- Patients who report a hearing deficit at baseline, even if it does not require a
hearing aid or intervention, or interfere with activities of daily life (Common
Terminology Criteria for Adverse Events [CTCAE] grade 2 or higher)

- Peripheral neuropathy > CTCAE grade 1

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to cisplatin, docetaxel, or other agents used in the study

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, uncontrolled diabetes, symptomatic congestive heart failure, unstable
angina pectoris, cardiac arrhythmia, or psychiatric/social situations that would
limit compliance with study requirements

- HIV-positive patients on combination antiretroviral therapy are ineligible

- Inability to comply with study and/or follow-up procedures

Type of Study:

Interventional

Study Design:

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

Change in FLT uptake (measured in quantitative SUVs and Ki)

Outcome Description:

Will be calculated by subtracting the uptake of the scan after the first cycle of chemotherapy from the uptake of the pre-treatment scan.

Outcome Time Frame:

Baseline and 6 weeks

Safety Issue:

No

Principal Investigator

Richard Wahl

Investigator Role:

Principal Investigator

Investigator Affiliation:

Johns Hopkins University

Authority:

United States: Food and Drug Administration

Study ID:

NCI-2012-02899

NCT ID:

NCT00963807

Start Date:

September 2009

Completion Date:

Related Keywords:

  • Recurrent Non-Small Cell Lung Cancer
  • Stage IB Non-small Cell Lung Cancer
  • Stage IIA Non-small Cell Lung Cancer
  • Stage IIB Non-small Cell Lung Cancer
  • Stage IIIA Non-Small Cell Lung Cancer
  • Stage IV Non-Small Cell Lung Cancer
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms

Name

Location

Johns Hopkins University Baltimore, Maryland  21205