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Non-Invasive Prediction of Microvascular Invasion (MVI) in Hepatocellular Carcinoma (HCC) by Assessment of Tumor Oxygenation by Blood Oxygen Level-Dependent Magnetic Resonance Imaging (BOLD MRI)


N/A
18 Years
N/A
Open (Enrolling)
Both
Hepatocellular Carcinoma

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Trial Information

Non-Invasive Prediction of Microvascular Invasion (MVI) in Hepatocellular Carcinoma (HCC) by Assessment of Tumor Oxygenation by Blood Oxygen Level-Dependent Magnetic Resonance Imaging (BOLD MRI)


Inclusion Criteria:



- Patients with known Hepatocellular Carcinoma;

- Scheduled to undergo liver resection or liver transplantation.

Exclusion Criteria:

- Estimated GFR (eGFR < 30 mL/min;

- MRI contrast allergy;

- General contraindications to MRI such as pacemaker, etc.;

- Prior tumor treatment such as transarterial chemoembolization or the tumor or
radiofrequency ablation or chemoradiation;

- Pregnancy;

- Age less than 18 years.

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

To assess the ability of BOLD MRI to predict microvascular invasion in hepatocellular carcinoma via assessment of intratumoral oxygenation.

Outcome Time Frame:

18 months

Safety Issue:

No

Principal Investigator

Kartik Jhaveri, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University Health Network, Toronto

Authority:

Canada: Health Canada

Study ID:

UHN09-0426-CE

NCT ID:

NCT00963612

Start Date:

September 2009

Completion Date:

March 2011

Related Keywords:

  • Hepatocellular Carcinoma
  • Carcinoma
  • Carcinoma, Hepatocellular

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