Surveillance of EBV Infection as a Risk Factor for PTLD in Pediatric and Adult Renal Transplant Recipients - a Multicenter Prospective Study
PTLD represents a heterogeneous group of abnormal lymphoid proliferations, generally of
B-cells, that occur in the setting of ineffective T-cell function because of pharmacological
immunosuppression. Because the vast majority of PTLDs are associated with Epstein-Barr virus
(EBV) infection, surveillance of EBV infection may have the potential to prevent the
development of PTLD by early intervention. However, the cut-off values of "high" EBV viral
load remain badly defined due to a lack of prospective studies and assay standardization.
The aim of this ongoing multicenter prospective study is the serial detection of primary EBV
infection or reactivation in a homogeneous patient population of pediatric renal transplant
recipients during the first 2 years posttransplant by the combined analysis of quantitative
EBV viral load by a standardized quantitative PCR technique, EBV serology and EBV-specific
T-lymphocytes for the identification of high-risk patients.
Observational Model: Cohort, Time Perspective: Prospective
EB viral load, serology and EBV-specific T cell in pediatric (and adult) renal transplant recipients with or without clinical symptoms of EBV, PTLD etc.
Burkhard Toenshoff, MD, PhD
University Children's Hospital of Heidelberg
Germany: Ethics Commission