Metabolism of Lipids in Advanced Cancer
18 Years
85 Years
Both
Lung Neoplasms, Cachexia
Trial Information
Metabolism of Lipids in Advanced Cancer
Weight loss in cancer is the result of breakdown of fat (lipid) and muscle protein reserves.
This research will explore how people with cancer use fat in their body through the use of
tracers and measures in the blood. A stable isotope of hydrogen called 'deuterium' is used
to trace the production of different fats by the liver. Other methods will determine how
much and what types of fat are transported around the body. Body composition will be
determined by CT scan and related to fat measures.
Inclusion Criteria:
- Low plasma phospholipids OR low plasma ratio of triglycerides to free fatty acids
- Recent weight loss
- Advanced stage lung cancer (Stage 3 or 4)
Exclusion Criteria:
- Having symptoms that may affect measures of fat metabolism (nausea, vomiting,
problems swallowing, etc.)
- Taking n-3 fatty acid supplements such as fish oil
Type of Study:
Observational
Study Design:
Observational Model: Case-Only, Time Perspective: Cross-Sectional
Outcome Measure:
Rate of hepatic de novo lipogenesis
Outcome Time Frame:
9 months
Safety Issue:
No
Principal Investigator
Vera Mazurak, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Alberta Health Services
Authority:
Canada: Health Canada
Study ID:
CIHR PIN 111846/ethics 24906
NCT ID:
NCT00962234
Start Date:
October 2009
Completion Date:
October 2011
Related Keywords:
- Lung Neoplasms
- Cachexia
- Lipogenesis
- Lipolysis
- Phospholipids
- Body Composition
- Nutritional Status
- Lipid Metabolism
- Cachexia
- Neoplasms
- Lung Neoplasms
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