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Metabolism of Lipids in Advanced Cancer

18 Years
85 Years
Not Enrolling
Lung Neoplasms, Cachexia

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Trial Information

Metabolism of Lipids in Advanced Cancer

Weight loss in cancer is the result of breakdown of fat (lipid) and muscle protein reserves.
This research will explore how people with cancer use fat in their body through the use of
tracers and measures in the blood. A stable isotope of hydrogen called 'deuterium' is used
to trace the production of different fats by the liver. Other methods will determine how
much and what types of fat are transported around the body. Body composition will be
determined by CT scan and related to fat measures.

Inclusion Criteria:

- Low plasma phospholipids OR low plasma ratio of triglycerides to free fatty acids

- Recent weight loss

- Advanced stage lung cancer (Stage 3 or 4)

Exclusion Criteria:

- Having symptoms that may affect measures of fat metabolism (nausea, vomiting,
problems swallowing, etc.)

- Taking n-3 fatty acid supplements such as fish oil

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Outcome Measure:

Rate of hepatic de novo lipogenesis

Outcome Time Frame:

9 months

Safety Issue:


Principal Investigator

Vera Mazurak, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Alberta Health Services


Canada: Health Canada

Study ID:

CIHR PIN 111846/ethics 24906



Start Date:

October 2009

Completion Date:

October 2011

Related Keywords:

  • Lung Neoplasms
  • Cachexia
  • Lipogenesis
  • Lipolysis
  • Phospholipids
  • Body Composition
  • Nutritional Status
  • Lipid Metabolism
  • Cachexia
  • Neoplasms
  • Lung Neoplasms