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Search for Genetic Factors Predictive of Response to Chemotherapy in Patients With or Who Has a Mammary Adenocarcinoma in Neo-adjuvant or Metastatic Setting


N/A
18 Years
N/A
Open (Enrolling)
Female
Breast Cancer

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Trial Information

Search for Genetic Factors Predictive of Response to Chemotherapy in Patients With or Who Has a Mammary Adenocarcinoma in Neo-adjuvant or Metastatic Setting


OBJECTIVES:

- Identify constitutional gene variants associated with a change in response.

OUTLINE: Blood samples are collected periodically for analysis of genetic factors.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Histologically confirmed breast carcinoma

- Received first-line chemotherapy (in neoadjuvant or metastatic setting) comprising
anthracyclines and/or taxanes, including for a second primary cancer

- Patient agrees to conservative surgery

- Hormone receptor status not specified

PATIENT CHARACTERISTICS:

- Menopausal status not specified

- No contraindication for chemotherapy comprising anthracyclines and/or taxanes

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- No prior adjuvant therapy

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Histologic complete response (Chevallier and Sataloff) or tumor response (RECIST)

Safety Issue:

No

Principal Investigator

Jacques Bonneterre, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Centre Oscar Lambret

Authority:

Unspecified

Study ID:

CDR0000633531

NCT ID:

NCT00959556

Start Date:

November 2007

Completion Date:

Related Keywords:

  • Breast Cancer
  • recurrent breast cancer
  • stage IA breast cancer
  • stage IB breast cancer
  • stage II breast cancer
  • stage IIIA breast cancer
  • stage IIIB breast cancer
  • stage IIIC breast cancer
  • stage IV breast cancer
  • Breast Neoplasms

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