Trial Information

Validation Study of Modeled Intra-pelvic Organ Motion During External Beam Radiotherapy for Cervix Cancer Using Frequent Magnetic Resonance Imaging

At simulation: patients will have two MRI scans in addition to the standard planning CT
scan. One MRI scan will be with bladder full, the other will be with bladder empty. During
treatment: patients will have two or three MRI scans per week at their convenience. MRI
scans will be scheduled close to radiotherapy treatment times to minimise inconvenience for
the patient. On the same day they have an MRI scan, they will also have a CBCT at the time
of treatment. None of the images will be used to alter or influence the treatment the
patient is receiving. If the patient feels that the imaging schedule is too inconvenient,
they will be given the option to reduce the frequency of the scanning or to withdraw from
the study.All the images will be loaded onto a password secure server. The MRI scans will be
fused to the planning CT scan using bone-to-bone matching. Tumour and intra-pelvic organs
will be contoured on the MRI scans. The contours will be used to create surface meshes of
each organ and with research software, we will be able to model the motion and deformation
of these organs over the course of radiotherapy. Using this data, we will be able to
simulate the dose impact of the organ motion on different intensity-modulated radiotherapy
plans. We will also explore the impact of bladder & rectal filling on tumour motion.