Letrozole Versus Laparoscopic Ovarian Diathermy for Ovulation Induction in Clomiphene-resistant Women With Polycystic Ovary Syndrome
In the letrozole group, withdrawal bleeding was achieved using 10 mg of dydrogesterone
tablets for 10 days before stimulation, then 2.5 mg of letrozole oral tablets (Femara;
Novartis Pharma Services, Switzerland) daily from day 3 of the menses for 5 days up to six
cycles. All patients in the control group underwent laparoscopic ovarian diathermy, then
followed up for 6 months.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
occurrence of ovulation and midcycle endometrial thickness (mm).
Hatem Abu Hashim, MD. MRCOG
Mansoura University Hospitals
Egypt: Institutional Review Board