Inclusion Criteria:

- Metastatic pancreatic cancer

- Glucose 6 phosphate dehydrogenase status normal

- ECOG performance status 0-2

- Normal creatinine and transaminase

- Women of child-bearing potential confirm negative pregnancy test

Exclusion Criteria:

- Concurrent chemotherapy or radiotherapy

- Significant co-morbid disorders

- Significant psychiatric symptoms

- Prior treatment with gemcitabine

- Concurrent chronic use of immunosuppressive agents (methotrexate,
cyclosporine,corticosteroids)

- Regular use of nonsteroidal anti-inflammatory agents

- Smoking more than 1 pack per day

- Excessive alcohol or drug use

- Enrollment in other experimental therapy

- Active infection

- Patients experiencing ongoing response to recent treatments