Clinical Correlates of Immunologic Responses to the Flu Vaccine
- To examine the incidence rate of influenza infection over two flu seasons in patients
who have undergone hematopoietic stem cell transplantation at the City of Hope National
- To correlate influenza infection with graft-vs-host disease, age, and transplant type
in these patients.
- To examine and compare the incidence rate of influenza in healthy volunteers to the
incidence rate in these patients.
OUTLINE: Beginning approximately 2 weeks after vaccination or the onset of flu season,
patients and healthy participants undergo nasopharyngeal washes every 14-17 days (2-10
washes) during the months of November-March of the 2008-2009 and 2009-2010 flu seasons.
Samples are analyzed by direct fluorescent antibodies.
Patients and participants complete case report forms detailing flu-like symptoms experienced
in the 2 weeks before sample collection.
PROJECTED ACCRUAL: A total of 150 patients and 75 healthy volunteers will be accrued for
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Incidence of influenza infection in patients and healthy volunteers
Aprille Seidel, PhD
Beckman Research Institute
United States: Institutional Review Board
|City of Hope Comprehensive Cancer Center||Duarte, California 91010|