Inclusion Criteria:

- Signed informed consent

- Histologically proven gastric adenocarcinoma

- Measurable or evaluable, inoperable locally advanced or metastatic disease. Presence
of at least one measurable lesion according to RECIST criteria.

- No previous palliative chemotherapy and/or immunotherapy

- Life expectancy of more than 3 months

- Age ≥ 18 years.

- ECOG performance status 0 - 2

- Ability to understand and comply with requirements of study protocol and trial
participation

- Patients of either sex are eligible for study entry. Women of childbearing potential
must have a negative pregnancy test at screening and must use effective contraception
(e.g. intrauterine device (IUD), birth control pills, or barrier device) beginning 2
weeks prior to first dose of study drug until 6 months after the final dose of study
drug.

- Hematological status:

Leucocytes ≥ 3 x 109/l Platelets ≥ 100 x 109/l •Renal function: Serum creatinine: ≤ 1.5 x
upper normal limit of normal (ULN)

•Hepatic function: AST and ALT: < 2.5 x ULN or < 5 x ULN if hepatic metastases are present
Alkaline phosphatase: < 2.5 x ULN or < 5 x ULN if hepatic metastases are present Total
bilirubin level ≤ 1.5 x ULN

- Patient must have an INR ≤ 1.5 and aPTT ≤ 1.5 x ULN within 7 days prior to
randomisation

- Baseline evaluations performed before treatment start: clinical and blood evaluations
no more than 7 days prior to planned first course; tumoral assessment (CT scan or
MRI) no more than 4 weeks prior to planned first course

Exclusion Criteria:

- Pregnant or lactating women.

- Women of child-bearing potential and men not using effective contraception.

- Concurrent cancer therapy (chemotherapy, radiation therapy, immunotherapy, biologic
therapy) or

- Neo/Adjuvant treatment with Irinotecan and/or docetaxel and/or Bevacizumab

- Patients with locally advanced disease who are candidates for curative therapy
(including operation and/or chemotherapy and/or radiotherapy).

- Prior history of chronic enteropathy, chronic diarrhea, unresolved bowel obstruction/
subobstruction, or extensive abdominopelvic radiation therapy.

- Previous malignancy other than gastric cancer in the last 5 years except curatively
treated basal cell carcinoma of the skin and/or in situ carcinoma of the cervix.

- Evidence of CNS metastasis at baseline. A CT or MRI scan within 28 days prior to
randomisation is mandatory to exclude CNS involvement in case of clinical suspicion
of CNS metastasis.

- Peripheral neuropathy (NCI CTC grade ≥ 1).

- Inadequate renal function:

- adequate renal function:ould be ≥ 60 mL/min. The Cockroft and Gault formula is
recommended for calculation of creatinine clearance. Patients with a creatinine
clearance just below 60 ml/min may be eligible if a measured creatinine clearance
(based on 24 hour urine collection or other reliable method) is ≥ 60 mL/min.

- Urine dipstick for proteinuria should be < 2+. Patients with ≥ 2+ proteinuria on
dipstick urinalysis at baseline should undergo 24 hour urine collection and must
demonstrate < 1 g of protein/24 hr.

- Serious medical or psychiatric disorders that would interfere with the patient's
informed consent or compliance with the requirements of the protocol or that
contraindicates the use of an investigational drug or puts the patient at high risk
for treatment-related complications.

- Active bacterial, viral or fungal infection (including acute or chronic-active
infection with HBV or HCV).

- Acute intra abdominal inflammatory process.

- Uncontrolled hypertension (systolic > 150 mm Hg and/or diastolic > 100 mm Hg) or
clinically significant (i.e. active) cardiovascular disease, for example
cerebrovascular accidents (≤ 6 months prior to randomisation), myocardial infarction
(≤ 6 months prior to randomisation), unstable angina, New York Heart Association
Grade II or greater congestive heart failure, or serious cardiac arrhythmia
uncontrolled by medication or potentially interfering with protocol treatment.

- Prior history of hypertensive crisis or hypertensive encephalopathy.

- Evidence of tumour invading major blood vessels on imaging. The investigator or the
local radiologist must exclude evidence of tumour that is fully contiguous with,
surrounding, or extending into the lumen of a major blood vessel (e.g. pulmonary
artery or superior vena cava).

- Serious uncontrolled coagulation disorder or thrombo-embolic complications (history
of embolisms or thromboses) within 6 months prior to study start or history of
inherited bleeding diathesis or coagulopathy with the risk of bleeding.

- Major surgical procedures within 4 weeks prior to study entry or planned major
surgical procedures throughout the course of the study. Patients must have fully
recovered from any surgical procedures conducted prior to 4 weeks before study entry.

- Minor surgery, including insertion of an indwelling catheter, within 48 hours prior
to the first bevacizumab infusion.

- Concurrent or recent (within 10 days) anticoagulant therapy. Prophylactic use of
anticoagulants is allowed.

- Chronic daily treatment with aspirin (> 325 mg/day) or clopidogrel (> 75 mg/day).

- Chronic daily treatment with oral corticosteroids (dose of > 10 mg/day
methylprednisolone equivalent). Inhaled steroids and short courses of oral steroids
for anti-emesis or as an appetite stimulant are allowed.

- Known history of Deep Vein Thrombosis (DVT) and/ or pulmonary embolism (PE).

- Non-healing wound, active peptic ulcer or bone fracture.

- History of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess
within 6 months of enrolment or active gastrointestinal bleeding.

- Concurrent treatment with an investigational drug or participation in another
clinical trial.

- Contraindications for the study regimen or known hypersensitivity to the study drugs
or to Chinese hamster ovary cell products or to other recombinant human or humanised
antibodies.