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Implication of Metabolic and Genomic Modifications in Elderly Subjects


N/A
60 Years
N/A
Not Enrolling
Both
Insulin Sensitivity, Aging

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Trial Information

Implication of Metabolic and Genomic Modifications in Elderly Subjects


Inclusion Criteria:



- Volunteers from the cohort aging SUVIMAX 2

- Men and Women

- over 60 years

- BMI between 18 and 35 kg/m2 (including terminals)

- Normal medical check up

- Blood pressure < 140/90 mmHg

- Normal glycemia, lipid profile

- sedentary or moderate physical activity (maximum 4 hours per week)

Exclusion Criteria:

- Biological results or anormal chek-up

- medical or surgical history not compatible with study

- severe digestive, cardiovascular, renal, liver or tumor disorders history in the 5
last years

- infectious or inflammatory disease within 2 months

- surgical history within 3 months

- bood donation within 2 months

- coagulation disease, anticoagulant or antiplatelet agents (aspirin ...) treatment

- xylocaïn allergy

- claustrophobia

- Drug that could affect insulin sensitivity (beta blockers, lipid lowering, oral
antidiabetics, insulin, , steroids)

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Outcome Measure:

Comparison of metabolic profile (lipid metabolism and energy expenditure) and insulin sensitivity based on the aging quality

Outcome Time Frame:

120 minutes

Safety Issue:

No

Principal Investigator

Martine LAVILLE, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Centre de recherche en nutrition humaine Rhône-Alpes

Authority:

France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Study ID:

2008.547

NCT ID:

NCT00951392

Start Date:

May 2009

Completion Date:

November 2009

Related Keywords:

  • Insulin Sensitivity
  • Aging
  • Insulin sensitivity
  • aging
  • lipid metabolism
  • hyperinsulinemic clamp
  • gene expression
  • sirtuins
  • Insulin Resistance

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