Inclusion Criteria:

- Donors of any age providing either a first or second BM or PBSC donation

- Meet donation criteria per institution policies and procedures

- Willing to receive phone follow-up at 1, 6, and 12 months

- Signed informed consent for study participation

For the HRQoL ancillary study, inclusion criteria:

- Related donors age greater than or equal to 5, eligible and consented to the primary
trial by the above listed inclusion criteria

- Donors competent to answer psychological assessment questions by themselves, or if a
child, should be able to respond to psychological assessment questions and have an
appropriate proxy also able to complete the HRQoL proxy interview

- English speaking

- Access to a telephone

- Willing to participate in pre-donation, 1 month and 1 year follow-up interviews

- Signed informed consent for study participation in ancillary study

Exclusion Criteria:

- Per institutional guidelines

- Donors providing unstimulated peripheral blood stem cells or lymphocytes

For the HRQoL ancillary study, exclusion criteria:

- Children less than or equal to 4 years of age