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Combined Haploidentical-Cord Blood Transplantation for Adults and Children

1 Year
Open (Enrolling)
Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, Lymphoma

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Trial Information

Combined Haploidentical-Cord Blood Transplantation for Adults and Children

Inclusion Criteria:

Patients will be eligible for this study if they have any one of the diseases that are
known to be cured after allogeneic stem cell transplantation.

1. Relapsed or refractory acute leukemia (myeloid or lymphoid)

2. Acute leukemia in first remission at high-risk for recurrence

3. Chronic myelogenous leukemia in accelerated phase or blast-crisis

4. Chronic myelogenous leukemia in chronic phase

5. Recurrent or refractory malignant lymphoma or Hodgkin lymphoma

6. Chronic lymphocytic leukemia, relapsed or with poor prognostic features

7. Multiple myeloma

8. Myelodysplastic syndrome

9. Chronic myeloproliferative disease

10. Hemoglobinopathies

11. Aplastic anemia

Exclusion Criteria:

1. Zubrod performance status > 2

2. Life expectancy is severely limited by concomitant illness

3. Patients with severely decreased LVEF or impaired pulmonary function tests(PFT's)

4. Estimated Creatinine Clearance <50 ml/min

5. Serum bilirubin> 2.0 mg/dl or SGPT >3 x upper limit of normal

6. Evidence of chronic active hepatitis or cirrhosis

7. HIV-positive

8. Patient is pregnant

9. Patient or guardian not able to sign informed consent

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

To assess the rate of engraftment with combined haploidentical-cord blood

Outcome Time Frame:

60 days

Safety Issue:


Principal Investigator

Andrew Artz, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Chicago


United States: Institutional Review Board

Study ID:




Start Date:

October 2006

Completion Date:

June 2015

Related Keywords:

  • Leukemia
  • Myelodysplastic Syndrome
  • Multiple Myeloma
  • Lymphoma
  • Appropriate candidate for transplantation
  • An HLA-identical related or unrelated donor cannot be identified within an appropriate time frame.
  • Leukemia
  • Lymphoma
  • Multiple Myeloma
  • Neoplasms, Plasma Cell
  • Myelodysplastic Syndromes
  • Preleukemia



The University of Chicago Chicago, Illinois  60637