Inclusion Criteria

Inclusion criteria:

- Age between 18 and 70 years of age

- Histological diagnosis of GBM (grade IV astrocytoma based on the World Health
Organization [WHO] classification)

- No previous radiotherapy or chemotherapy

- No history of previous neoplasms

- Inoperable patients (tumour in place, biopsy only)

- KPS ≥ 70

- Adequate hematological, renal and hepatic function

- Absolute neutrophil count ≥ 1,500/mm3

- Platelets ≥ 100,000 per mm3

- Serum creatinine ≤ 1.5 times the upper limit of normal of the laboratory where
it is measured

- Total bilirubin ≤ 1.5 times the upper limit of normal of the laboratory where it
is measured

- Liver enzymes < 3 times the upper limit of normal of the laboratory where they
are measured

- Patients under corticosteroids must have received a stable or decreasing dose in the
14 days preceding randomization

- Consent form signed by the patients