Trial Information

Screening for Nasopharyngeal Carcinoma (NPC) on the High Risk Area and Evaluation on the Project of Early Diagnosis and Treatment

Sample selection

- Select communities of 70,000 to 120,000 populations in Sihui and Zhongshan City as our
fields by cluster sampling randomization

- Divide them into screening group and control group according to the areas of
administration

Participants recruitment

- Subjects voluntarily attend this screening study

- Informed consents are performed at the recruitment

Questionnaires

- Face-to-face interviews are conducted by well-trained investigators

Physical examinations

- Each participants are performed medical services such as otorhinolaryngologic and
lymphatic examinations

Serological tests

- Each blood samples are tested for IgA antibodies against EBV capsid antigen (VCA/IgA)
and IgA antibodies against EBV nuclear antigen 1 (EBNA1/IgA)

- If the results reach the serological definition of high-risk populations, fiberoptic
endoscopy and pathological biopsy were performed by otorhinolaryngologists

- The rest of the blood samples will be stored at the biobank of Sun Yat-sen University
Cancer Center

Follow up

- The cohort will follow up according to the screening protocol