Trial Information

Outlook: An Intervention to Improve Quality of Life in Serious Illness

Efforts to improve end-of-care often focus on pain and symptom control, but few, if any,
effective interventions exist addressing preparation and completion. We designed an
end-of-life preparation and completion intervention, based on the human development
literature identifying life completion as a developmental task and the robust evidence in
health communication and clinical psychology that addresses the value of expressing emotions
and stress on health outcomes. Our specific aims are 1) evaluate the impact of an
intervention that promotes discussions of end-of-life preparation and completion on health
outcomes in dying persons, including pain and symptoms, physical function, emotional
function (anxiety and depression), spiritual well-being, and quality of life at the end of
life and 2) evaluate the content of the such discussions, examining task variation
associated with gender, ethnicity, socio-economic status, quality of communication with
family, spirituality, and stage of illness to improve understanding of the need for tailored
intervention content based on demographics or location in the trajectory of illness. We
propose a randomized control trial to evaluate the intervention. 140 patients with advanced
cancer, CHF, ESRD, or COPD will be randomly assigned into one of two intervention groups and
complete a brief battery of pre-test measures. Subjects in the first group ("treatment")
will meet with a facilitator three times for a period of forty-five minutes each. In the
first session, subjects will be asked to discuss issues related to life review. A week
later, participants will be asked to speak in more depth about issues such as regret,
forgiveness and things left undone. In the final session, a week hence, subjects will focus
on heritage and legacy. The subjects in the second group ("attention control") will meet
with a facilitator three times for a period of forty-five minutes each and be asked to
listen to a non-guided relaxation CD. One week and two weeks later, participants in all
groups will receive post-test measures administered by a blinded interviewer.