Interest of the Dosage of CA 15-3 in CSF for Diagnosing Carcinomatous Meningitis in Breast Cancer
OBJECTIVES:
Primary
- Evaluate the validity of determining CA 15-3 levels in the cerebrospinal fluid (CSF)
using automated immuno-enzymatic methods.
Secondary
- Determine the sensitivity and specificity of these assays in assessing CA 15-3 in CSF.
- Assess favorability of intrathecal production of CA 15-3.
- Determine threshold interpretations of CA 15-3 levels in CSF.
OUTLINE: This is a multicenter study.
Within 15 days of suspected meningeal involvement, blood and cerebrospinal fluid samples are
collected. Samples are examined by immunoenzyme assays. Patients with suspected cases of
carcinomatous meningitis undergo cerebrospinal MRI.
Interventional
Masking: Open Label, Primary Purpose: Diagnostic
CA 15-3 levels in cerebrospinal fluid
No
Emilie Le Rhun
Principal Investigator
Centre Oscar Lambret
Unspecified
CDR0000633542
NCT00938756
April 2008
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