Phase II Study on Dose Escalated, Accelerated Hypofractionated Intensity Modulated Radiotherapy for Stage III Non-Small Cell Lung Cancer With Concurrent Chemotherapy
Inclusion Criteria:
- Pathologically proven (either histologic or cytologic) diagnosis of Stage IIIA or
IIIB non-small cell lung cancer; excluding patients with N3 disease based on
supraclavicular or contralateral hilar adenopathy, or significant pleural /
pericardial effusion.
Exclusion Criteria:
- Patients for whom treatment is planned with a maximum dose of ≥ 66 Gy to the
ipsilateral brachial plexus
- Greater than minimal, exudative, or cytologically positive pleural effusions
- ≥ 10% weight loss within the past month
- Prior invasive malignancy (with exceptions)
- Prior radiotherapy to the region of the study cancer
- Significant co-morbidities
- Pregnancy or women of childbearing potential and men who are sexually active and not
willing/able to use medically acceptable forms of contraception
- Known allergic reactions to components of planned chemotherapy regimen