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Prostate Cancer Prospective Cohort

18 Years
Open (Enrolling)
Prostate Cancer

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Trial Information

Prostate Cancer Prospective Cohort

DNA will be isolated from each person and then studied for the presence of certain genes
that may increase the chance of developing prostate cancer. Certain genes will also be
studied in patients with known prostate cancer to determine if they increase the chance of
cancer spreading to other parts of the body and decrease one's chance of being cured. Small
differences in genes can slightly affect their ability to function. While these differences
are normal, they may influence the way the cancer responds to therapy. An understanding of
which genes increase (or decrease) the chance of being cured of a disease, such as prostate
cancer, will improve our ability to take care of patients more effectively.

A second purpose of this study is to collect blood and cancer tissue for future studies.
While the small differences in genes may be the best marker of bad cancer, it is also
possible that proteins in blood or tumor may be a better marker.

Inclusion Criteria:

- Newly diagnosed patients: 1. newly diagnosis of prostate cancer 2. untreated except
for neoadjuvant systemic therapy.

Exclusion Criteria:

- Newly diagnosed patients: 1. inability to give informed consent

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Ability to recognize increased risk of metastatic prostate cancer based on specific genetic polymorphisms.

Outcome Time Frame:

At the time of prostate cancer diagnosis

Safety Issue:


Principal Investigator

Bettina Drake, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Washington University School of Medicine


United States: Institutional Review Board

Study ID:




Start Date:

May 2000

Completion Date:

June 2017

Related Keywords:

  • Prostate Cancer
  • Metastatic Prostate Cancer
  • Prostate Cancer Risk Assessment
  • Prostatic Neoplasms



Washington University School of MedicineSaint Louis, Missouri  63110