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Study of Natural Killer Cells Function in Untreated Patients With Chronic Lymphocytic Leukemia


N/A
18 Years
N/A
Not Enrolling
Both
Chronic Lymphocytic Leukemia

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Trial Information

Study of Natural Killer Cells Function in Untreated Patients With Chronic Lymphocytic Leukemia


Method: prospective, monocentric, descriptive study

Primary objective:

Evaluation of the expression and function of receptors activator of NK cell (KIRs) in
patients with CLL at stage A with therapeutic abstention, or stage B or C which require a
treatment.

Secondary objectives:

Measure of the evolution of cytotoxic function of NK cells and theirs biomarkers of
activation when the patient receives an immunochemotherapy with Rituximab/ Fludarabine/
Cyclophosphamide (RCF).

Verification, by analysis, of functions and biomarkers of the adaptive and innate immunity


Inclusion Criteria:



- Diagnosis of CLL (Score of Matutes >=4) with no history of treatment: Stade A of
Binet, Or Stade B or C before the beginning of the treatment with RFC

- Patients who can undergo blood collection

- Patient aged 18 years and older

- Signed consent

Non inclusion Criteria:

- Patient with anemia: haemoglobin < 9 g/dl

- Pregnancy, breast feeding

- Patient in an urgent situation, or unable to give a consent

Type of Study:

Interventional

Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Outcome Measure:

Analysis of the surface expression of functional biomarkers of the NK cell, functional study, analysis of expression of transcription of values genes.

Outcome Time Frame:

1 day

Safety Issue:

No

Principal Investigator

Thérèse AURRAN-SCHLEINITZ, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Institut Paoli-Calmettes

Authority:

France: Direction Générale de la Santé

Study ID:

LLC-NK/IPC 2007-004

NCT ID:

NCT00934986

Start Date:

March 2008

Completion Date:

September 2010

Related Keywords:

  • Chronic Lymphocytic Leukemia
  • Chronic Lymphocytic Leukemia
  • NK Cells
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid

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