Study of Natural Killer Cells Function in Untreated Patients With Chronic Lymphocytic Leukemia
Method: prospective, monocentric, descriptive study
Primary objective:
Evaluation of the expression and function of receptors activator of NK cell (KIRs) in
patients with CLL at stage A with therapeutic abstention, or stage B or C which require a
treatment.
Secondary objectives:
Measure of the evolution of cytotoxic function of NK cells and theirs biomarkers of
activation when the patient receives an immunochemotherapy with Rituximab/ Fludarabine/
Cyclophosphamide (RCF).
Verification, by analysis, of functions and biomarkers of the adaptive and innate immunity
Interventional
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Analysis of the surface expression of functional biomarkers of the NK cell, functional study, analysis of expression of transcription of values genes.
1 day
No
Thérèse AURRAN-SCHLEINITZ, MD
Principal Investigator
Institut Paoli-Calmettes
France: Direction Générale de la Santé
LLC-NK/IPC 2007-004
NCT00934986
March 2008
September 2010
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