Inclusion Criteria:

1. High-risk, locally advanced (TxN2b~3 or unresectable T4, M0) OSCC

2. Histologically confirmed squamous cell carcinoma

3. Performance status: Eastern Cooperative Oncology Group performance status (ECOG) 0-1

4. age 18 years or older, less than 70 years of age

5. Having signed informed consent

6. Measurable disease by CT or MRI

7. Adequate hematologic, hepatic and renal function

Exclusion Criteria:

1. Prior radiotherapy for targeted lesions, chemotherapy, EGFR pathway targeting therapy

2. Prior surgery for cancer except for the purpose of diagnostic biopsy

3. Concomitant active 2nd malignancies or disease-free of malignancies < 3 years before
the study except adequately treated in situ cervical cancer, or non-melanoma skin
cancer

4. Concomitant anticancer therapies within the past 28 days

5. Severe cardiopulmonary diseases and other systemic disease under poor control

6. Uncontrolled chronic neuropathy

7. Women who are positive of pregnancy, or in breast-feeding

8. Known allergy to any study treatment

9. Legal incapacity

10. Significant disease which, in the investigator's opinion, would exclude the patient
from the study