Study on the Incidence of Febrile Episodes During Stem Cells Collection After Chemotherapy in Patients With Multiple Myeloma
Inclusion Criteria:
1. Age > 18 and < 70 years
2. Diagnosis of multiple myeloma
3. ECOG < 2 to be evaluated at baseline, after the induction chemotherapy
4. Indication to the mobilization with high dose cyclophosphamide chemotherapy
5. Normal blood counts: neutrophils > 1500/μl; platelets > 100.000/μl; hemoglobin > 10
g/dl.
6. Liver and renal function: SGOT/AST, SGPT/ALT; bilirubin < 1.5 times the upper limit
of the normal ranges; creatinine < 2 times the upper limit of the normal ranges.
7. Interval from previous induction chemotherapy to high dose chemotherapy between 30
and 60 days
8. ECG e/o Echocardiogram within age related normal range
9. Negative HCV and HbsAg
10. Must be willing and able to fill in the patient's diary
11. Written informed consent
Exclusion Criteria:
1. Documented and/or suspected infections
2. Uncontrolled concurrent illness
3. Documented cardiac dysfunction