Inclusion Criteria:

1. Age > 18 and < 70 years

2. Diagnosis of multiple myeloma

3. ECOG < 2 to be evaluated at baseline, after the induction chemotherapy

4. Indication to the mobilization with high dose cyclophosphamide chemotherapy

5. Normal blood counts: neutrophils > 1500/μl; platelets > 100.000/μl; hemoglobin > 10
g/dl.

6. Liver and renal function: SGOT/AST, SGPT/ALT; bilirubin < 1.5 times the upper limit
of the normal ranges; creatinine < 2 times the upper limit of the normal ranges.

7. Interval from previous induction chemotherapy to high dose chemotherapy between 30
and 60 days

8. ECG e/o Echocardiogram within age related normal range

9. Negative HCV and HbsAg

10. Must be willing and able to fill in the patient's diary

11. Written informed consent

Exclusion Criteria:

1. Documented and/or suspected infections

2. Uncontrolled concurrent illness

3. Documented cardiac dysfunction