Inclusion Criteria:

- Near total or total thyroidectomy because of struma multinodsa (nodular goiter) with
or without substitution of thyroid hormone after operation

- Total thyroidectomy because of papillary carcinoma of thyroid gland (T1/T2
carcinoma, N1, M0) with planned radio-ablative therapy (RAT) without or with rhTSH

Exclusion Criteria:

- Pat< 18 years

- Immune disease of thyroid gland (Graves disease)

- Severe immunodeficiency

- Immunosuppressive medication because of solid Organ transplantation

- Hepatitis A/B/C or HIV

- All exclusion criteria for any surgical procedure