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Breast MRI Screening in High-Risk Women After Mantle Radiation Therapy for Lymphoma

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Breast Cancer

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Trial Information

Breast MRI Screening in High-Risk Women After Mantle Radiation Therapy for Lymphoma

Breast MRIs:

Breast MRIs have been reported to have higher sensitivity than mammograms for detecting
early breast cancers, particularly in dense breasts where mammograms are not as effective.
Although breast MRIs may add important information not provided by mammograms, the MRI must
be used selectively. This is because the MRI is very sensitive and may show a false
positive test (a test that shows cancer when there is none there).

Study Procedures:

If you are found to be eligible to take part in this study, the following procedures will be
performed 1 time a year.

- You will have a breast exam.

- You will have a mammogram. A mammogram is a breast x-ray used to detect breast cancer
and look for abnormalities in the breast.

- You will have an MRI of your breasts. For the MRI, you will lay on your stomach while
a large donut-shaped scanner takes images of your breasts.

If any abnormality is found, you will have routine follow-up procedures performed. Routine
follow-up may include additional imaging scans or biopsies. These will follow the standard
of care, and the information will be collected and stored in your medical record.

Length of Study:

You will be on study for 20 years, with annual check-ups with breast imaging studies at M.
D. Anderson. You will be taken off study if there is a change in your health that will not
allow a breast mammogram or MRI, such as becoming pregnant.

This is an investigational study.

Up to 223 patients will take part in this study. All will be enrolled at M. D. Anderson.

Inclusion Criteria:

1. Female patients diagnosed with lymphoma prior to 1995

2. The radiation therapy must have been delivered at M.D. Anderson from start to finish
with complete records of dose received

3. Patients must have received radiation therapy to the chest between the ages of 10 and

Exclusion Criteria:

1. Patients with claustrophobia

2. Obese patients (the equipment weight limit is 350 pounds and the maximum scanner bore
diameter is 55 cm)

3. Patients with myocardial infarction within 6 months of study entry

4. Patients with unstable angina pectoris, uncontrolled congestive heart failure, or
uncontrolled arrhythmias

5. Patients with aneurysm clips, pacemakers, or other implanted devices that are not MRI

6. Pregnant patients

7. Patients with compromised renal function, with a calculated glomerular filtration
rate (cGFR) less than 60 ml/min/1.73m2.

8. Patients who began their treatment outside of MD Anderson Cancer Center.

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Incidence of breast cancer detected with addition of breast MRI

Outcome Time Frame:

Once a year

Safety Issue:


Principal Investigator

Bouthaina Dabaja, MD

Investigator Role:

Study Chair

Investigator Affiliation:

UT MD Anderson Cancer Center


United States: Institutional Review Board

Study ID:




Start Date:

June 2009

Completion Date:

October 2011

Related Keywords:

  • Breast Cancer
  • Breast Cancer
  • Hodgkin's lymphoma
  • Mantle-field Irradiation
  • Mammogram
  • Magnetic resonance imaging
  • MRI Breast Cancer Screening
  • Breast Neoplasms



UT MD Anderson Cancer Center Houston, Texas  77030