Acceptability and Feasibility of a Modified HPV Vaccine Schedule in Brothel Based Female Sex Workers in Peru
FSWs are at higher risk of HPV infection and presumably cervical cancer, and the recently
available vaccine has been shown to protect against persistent infection from these types.
If this study gives evidence showing the vaccine is acceptable in preventing cervical HPV
infection by types 16 and 18 in this population, then the burden of cervical cancer and
cancer precursors could be drastically decreased through widespread vaccination of this
target group. Vaccination at the point of entry of brothel based sex work may become a
requirement to lower the burden of cervical cancer among FSWs and also among all other sex
partners of clients of FSWs. A modified schedule may prove beneficial for FSWs in Peru to
complete the vaccine regimen.
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Antibody Response to HPV Vaccine for HPV 6,11,16,18.
We measured anitbody response to HPV vaccine for HPV subtypes 6,11,16, and 18. This was compared by study arm, namely the regular and modified vaccination schedules.
Neal Halsey, MD
Johns Hopkins Bloomberg School of Public Health
United States: Institutional Review Board
Merck IISP 35706