Inclusion Criteria:

- Age >16 years

- Lung nodule (s) identified on CT scan

- Clinical decision to obtain tissue biopsy of lung lesion

- CT guided biopsy not preferred technique (previous negative CT guided biopsy or
technically difficult nodule location or perceived high risk of pneumothorax or other
complications)

- Pleural based lesion only if: Inaccessible by CT guided biopsy or previous CT guided
biopsy non-diagnostic

Exclusion Criteria:

- Lack of informed consent

- Nodule less than 1 cm or greater than 6 cm long axis

- Mediastinal adenopathy >2cm short axis on CT chest

- Evidence of endobronchial abnormality on chest CT

- Medical contraindication to bronchoscopy

- Patients with lesions highly suspicious for lung cancer, potentially resectable with
lobar or lesser resection and without significantly increased operative risk factors
will not be entered into this study prior to surgical evaluation.

- Patient with implanted electronic medical device

- Uncontrolled or irreversible coagulopathy (platelets <100, INR >1.3, use of
clopidogrel in the 7 days prior to bronchoscopy)

- Confirmed or suspected pregnancy