The Effects of Maintenance Schedules Following Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease
This will be a randomised, controlled, parallel study of a maintenance pulmonary
rehabilitation (PR) programme in patients with chronic obstructive pulmonary disease (COPD).
Following successful completion of a PR programme in Norwich(see below) patients will be
randomised to receive maintenance PR or standard medical care.
Prior to enrolment in the PR programme, patients will undergo standard baseline assessments,
after providing informed consent. These will include a medical examination, demographic
details, past medical history, spirometry, an incremental shuttle walk test (ISWT) to
determine a predicted maximum oxygen consumption, an endurance shuttle walk test (ESWT) at
85% of predicted maximum oxygen consumption (V02), chronic respiratory questionnaire (CRQ),
EuroQol (EQ5D), hospital anxiety and depression score (HADS), serum interleukin(IL)-6 and
C-reactive protein (CRP), body mass index (BMI), skinfold thickness and muscle strength.
At the end of PR and twelve months following PR patients will undergo medical examination,
ESWT at 85% of predicted maximum VO2, CRQ, EQ5D, HADS, serum interleukin(IL)-6 and CRP, BMI,
skinfold thickness and muscle strength and an assessment of activity in the preceding month.
At 3 months, 6 months and 9 months following PR patients will complete the CRQ and a
questionnaire to assess activity in the preceding month. These will be undertaken by postal
Baseline socioeconomic and costs questionnaire will be completed at entry to the PR and
follow-up cost questionnaires will be completed following PR and after 3, 6, 9 and 12
months. Patients will be given a diary card on which to record NHS contacts, prescriptions
etc at all visits.
The 3, 6 and 9-month questionnaires will be collected by post.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
The primary endpoint will be change from baseline in the dyspnoea domain of the Chronic Respiratory Questionnaire (CRQ).
Andrew Wilson, MD MRCP (UK)
Clinical Senior Lecturer, University of East Anglia
United Kingdom: National Health Service