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Hematologic Malignancy Biology Study


N/A
N/A
75 Years
Open (Enrolling)
Both
Hematologic Malignancy

Thank you

Trial Information

Hematologic Malignancy Biology Study


Background

Laboratory-based investigations have contributed to an improved understanding of
pathophysiology and to the development of new therapies for hematologic malignancies.

The aim of this protocol is to facilitate biologic study of leukemias, myelodysplastic
syndromes, lymphomas, and other blood disorders.

This is a sample acquisition protocol for targeted study of hematologic malignancies by a
collaborative network of NIH investigators from multiple Institutes/Centers.

Objectives

This biology protocol is designed to allow sample acquisition for use in the study of
hematologic malignancies. A variety of laboratory investigations designed to support NIH
translational trials; to apply new methodologies in the study of cellular, molecular,
genetic, and genomic biology; to probe for new therapeutic targets; and to develop new
treatment approaches will be performed.

Eligibility

Diagnosis of any hematologic malignancy or pre-malignant blood disorder, including but not
restricted to the following: Acute Lymphocytic Leukemia (ALL), Acute Myelogenous Leukemia
(AML), Myelodysplastic Syndrome (MDS), Chronic Myelogenous Leukemia (CML), Juvenile
Myelomonocytic Leukemia (JMML, J-CML), Non-Hodgkin's Lymphoma (NHL), Hodgkin's Disease

Tumor tissue that has been previously collected and is available for study or that can be
collected with minimal additional risk to the subject during sampling required for routine
patient care.

Patient age: birth to 75 years.

Design

Biologic assays relevant to the investigation of hematologic malignancies will be performed
in an exploratory fashion, some studies are developmental, i.e., assay design in support of
current or planned CC clinical trials. Others are standard assays that will be applied in
attempt to identify new targets or test new therapeutic approaches.

.

Inclusion Criteria


- INCLUSION CRITERIA

Diagnosis of any hematologic malignancy or pre-malignant blood disorder, including but not
restricted to the following:

Acute Lymphocytic Leukemia (ALL)

Acute Myelogenous Leukemia (AML)

Myelodysplastic Syndrome (MDS)

Chronic Myelogenous Leukemia (CML)

Juvenile Myelomonocytic Leukemia (JMML, J-CML)

Non-Hodgkin's Lymphoma (NHL)

Hodgkin's Disease

Tumor tissue that has been previously collected and is available for study or that can be
collected with minimal additional risk to the subject during sampling required for routine
patient care.

Patient age: birth to 75 years.

Prior therapy: no restrictions

Informed consent or IRB waiver of the requirement for informed consent for specific
research studies.

EXCLUSION CRITERIA

None

Type of Study:

Observational

Study Design:

N/A

Principal Investigator

Alan S Wayne, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Cancer Institute (NCI)

Authority:

United States: Federal Government

Study ID:

040102

NCT ID:

NCT00923442

Start Date:

January 2004

Completion Date:

Related Keywords:

  • Hematologic Malignancy
  • Leukemia
  • Biology Study
  • Lymphoma
  • Myelodysplastic Syndrome
  • Acute Lymphoblastic Leukemia
  • Acute Lymphocytic Leukemia
  • Pediatric Blood Disorders
  • Hodgkins Lymphoma
  • Non-Hodgkins Lymphoma
  • MDS
  • Neoplasms
  • Hematologic Neoplasms

Name

Location

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland  20892