Does Low-frequency Electro-acupuncture Restore Sensitivity of the Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome
Aim 1. Elucidate if low-frequency EA induce ovulation and restore LH frequency and amplitude
as well as sex steroid secretion as compared to a control group receiving same amount of
Aim 2. Elucidate if low-frequency EA restore cortisol frequency and amplitude compared to a
control group receiving same amount of attention.
Aim 3. Elucidate if low-frequency EA restore psychological distress and quality of life as
compared to a control group receiving same amount of attention.in women with PCOS.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Frequent blood sampling every 10th minute during an overnight stay in order to measure changes in LH and cortisol pulsatility before and after treatment. A third assessment will be made in those participants who ovulate during the 14 week study.
Sweden: Regional Ethical Review Board