Inclusion Criteria:

- Male or female, aged between 18 and 65 years;

- Radiographic evidence on cranial MRI of a single contrast-enhancing unilateral
supratentorial cerebral tumor;

- Karnofsky Performance Score of 60 or higher;

- Willing to practice an effective method of birth control for at least 12 months after
wafer implantation surgery;

Exclusion Criteria:

- More than one focus of tumor or tumor crossing the midline, as assessed by coronal
cranial MRI scan;

- Prior radiotherapy to the brain;

- Prior chemotherapy for the malignant glioma before the baseline evaluation, or
patients who were being treated with chemotherapeutic agents;

- Known hypersensitivity to nitrosoureas;

- Participation in any other investigational protocol in the previous 6 months for any
type of malignancy;