Inclusion Criteria:

- Breast cancer histologically proven by a 14 G or 16 G micro-biopsy to have
confirmation of the diagnosis, evaluation histology prognosis grade, hormone
receptors and to obtain a sample for the study of biological factors.

- Menopausal patients as defined as follows:

- Natural menopause >= 1 year, or

- Surgical ovariectomy.

- T unilateral tumor> 3 cm, N 1-2, M0 or M +, non-inflammatory.

- Hormone receptor positive. RE positive or PR positive with histochemical technique (+
10% of cells express the receptor)

- No previous treatment of the disease by chemotherapy, hormone therapy, surgery or
radiotherapy. Discontinuation of replacement therapy of menopause for at least 1
month

- Age>= 60 years

- Evaluable disease

- Performance Status <= 2

- Biological function using the following criteria:

- neutrophils >= 2.10E9 / l,

- Platelets> = 100.10E9 / l,

- Hemoglobin> = 10 g / dl,

- Creatinine <= 1.5 x upper normal,

- Total bilirubin <= 1.25 x the upper normal

- Transaminases (AST and ALT) <= 1.5 x upper normal,

- Alkaline phosphatase <= 2.5 x upper normal.

- Cardiac Function: electrocardiogram (ECG) normal.

- Signed written consent before any procedure related to the study.

Exclusion Criteria:

- Men

- Non Menopausal Patients

- Patients with hormone receptor negative: PR- and RE -

- Contra-indication to anti-estrogens (risk thrombi arteria)

- Tumor <3 cm operable

- Tumor inflammatory T4d (PEV 2 or 3).

- Extensive hepatic lesions (> 1 / 3 of liver volume)

- Uncontrolled cardiac disease such as angina, congestive heart failure, or arrhythmia
requiring medical treatment or history of myocardial infarction within 3 months
before.

- History of cancer except skin cancer and basal cell cancer in situ of the cervix (a
contralateral breast cancer had been no systemic treatment will be admitted).

- Chronic diseases (somatic or psychiatric) in poor prognosis.

- Patients who for reasons of family, social, geographical or psychological can not be
followed properly.

- Patients under law protection